Dr. Allan Blake - Resume & Research

Axen, K.V., Schubart, U.K., Blake, A.D. and Fleischer, N. (1983) Role of Ca2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets.
Journal of Clinical Investigation 72:13-21.

Blake, A.D. and Strader, C.D. (1986) Potentiation of specific association of insulin with HepG2 cells by phorbol esters. Biochemical Journal 236:227-234.

Dixon, R.A.F., Sigal, I.S., Rands, E., Register, R.B., Candelore, M.R., Blake, A.D. and Strader, C.D. (1987) Ligand binding to the b-adrenergic receptor involves its rhodopsin-like core. Nature 326:73-77.

Strader, C.D., Sigal, I.S., Blake, A.D., Cheung, A.H., Register, R.B., Rands, E., Zemcik, B.A., Candelore, M.R. and Dixon, R.A.F. (1987) The carboxy terminus of the hamster beta-adrenergic receptor expressed in L cells is not required for receptor sequestration. Cell 49:855-863.

Blake, A.D., Hayes, N.S., Slater, E.E. and Strader, C.D. (1987) Insulin receptor desensitization correlates with attenuation of tyrosine kinase activity but not of receptor endocytosis. Biochemical Journal 245:357-364.

Blake, A.D., Mumford, R.A., Strout, H.V., Slater, E.E. and Strader, C.D. (1987) Synthetic segments of the b-adrenergic receptor are preferentially recognized by cAMP-dependent protein kinase or protein kinase C. Biochemical and Biophysical Research Communications 147:166-173.

Strader, C.D., Dixon, R.A.F., Cheung, A.H., Candelore, M.R., Blake, A.D. and Sigal, I.S. (1987) Mutations that uncouple the b-adrenergic receptor from Gs and increase agonist affinity.
Journal of Biological Chemistry 262:16439-16443.

Blake, A.D. and Smith, R.G. (1991) Desensitization studies using perifused rat pituitary cells show that growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 stimulate growth hormone release through distinct receptor sites. Journal of Endocrinology 129:11-19.

Blake, A.D., Anthony, N.M., Chen, H.H., Harrison, J.B., Nathanson, N.M. and Sattelle, D.B. (1993) A Drosophila nervous system muscarinic acetylcholine receptor: transient functional expression and localization by immunocytochemistry. Molecular Pharmacology 44:716-724.

Blake, A.D. (1994) Functional characterization of a cloned Drosophila muscarinic acetylcholine receptor. Doctoral Dissertation, University of Cambridge, UK.

Harrison, J.B., Chen, H.H., Blake, A.D., Huskisson, N.S., Barker, P. and Sattelle, D.B. (1995) Localization in the nervous system of Drosophila melanogaster of a C-terminus anti-peptide antibody to a cloned Drosophila muscarinic acetylcholine receptor. Journal of Neuroendocrinology 7:347-352.

Reisine, T., Law, S.F., Blake, A.D. and Tallent, M. (1996) Molecular mechanisms of opiate receptor coupling to G proteins and effector systems. Annals of the New York Academy of Sciences 780:168-175.

Tallent, M., Blake, A.D. and Reisine, T. (1996) Molecular Biology of Opiate Receptors. In: Recombinant cell surface receptors: Focal point for therapeutic intervention. pp 35-55, Ed. M.J. Browne, R.G. Landes, UK.

Blake, A.D., Bot, G. and Reisine, T. (1996) Structure-function analysis of the cloned opiate receptors: Peptide and small molecule interactions. Chemistry and Biology 3:967-972.

Blake, A.D., Bot, G., Freeman, J.C. and Reisine, T. (1997) Differential opioid agonist regulation of the mouse m opioid receptor. Journal of Biological Chemistry 272:782-790.

Blake, A.D., Bot, G., Li, S., Freeman, J. C. and Reisine, T. (1997) Differential agonist regulation of the human k opioid receptor. Journal of Neurochemistry 68:1846-1852.

Bot, G., Blake, A.D., Li, S. and Reisine, T. (1997) Opioid regulation of the mouse d opioid receptor expressed in HEK 293 cells. Molecular Pharmacology 52:272-281.

Blake A.D., Bot, G. and Reisine, T. (1997) Molecular pharmacology of the opioid receptors. In: Molecular neurobiology of pain. Progress in Pain Research and Management, volume 9, pp 259-273, Ed. D. Borsook, International Association for the Study of Pain Press, USA.

Blake, A.D., Bot, G., Tallent, M., Law, S.F., Li, S., Freeman, J.C. and Reisine, T. (1997) Molecular regulation of the opioid receptors. Receptors and Channels 5:231-235.

Bot, G., Blake, A.D., Li, S. and Reisine, T. (1998) Mutagenesis of a single amino acid in the rat m opioid receptor discriminates ligand binding. Journal of Neurochemistry 70:358-365.

Bot, G., Blake, A.D., Li, S. and Reisine, T. (1998) Mutagenesis of the mouse d opioid receptor converts (-)buprenorphine from an agonist to an antagonist. Journal of Pharmacology and Experimental Therapeutics 284:283-290.

Bot, G., Blake, A.D., Li, S. and Reisine, T. (1998) Fentanyl and its analogs desensitize the cloned m-opioid receptor. Journal of Pharmacology and Experimental Therapeutics 284:1207-1218.

Bot, G., Blake, A.D. and Reisine, T. (1998) Stimulation of peptidergic receptors by peptide hormones and neurotransmitters: Studies of opioid receptors. In: Proteolytic and cellular mechanisms in prohormone and neuropeptide precursor processing, pp 191-211. Ed. V.Y.H. Hook, R.G. Landes Bioscience Publishers, Springer-Verlag, Heidelberg.

Rohrer, S.P., Birzin, E.T., Mosley, R., Berk, S., Hutchins, S., Shen, D.-M., Xiong, Y., Hayes, E.C., Parmar, R.M., Foor, F., Mitra, S., Degrado, S., Shu, M., Klopp, J., Cai, S.-J., Blake, A., Chan, W.W.-S., Pasternak, A., Patchett, A.A., Smith, R.G., Chapman, K. and Schaeffer, J.M. (1998) Integration of high throughput screening and combinatorial chemistry for rapid identification of somatostatin receptor subtype selective analogs. Science 282: 737-740.

Parmar, R.M., Chan, W.W.-S., Dashkevicz, M., Hayes, E.C., Rohrer, S.P., Smith, R.G., Schaeffer, J.M. and Blake, A.D. (1999) Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from anterior pituitary cells. Biochemical and Biophysical Research Communications 263:276-280.

Strowski, M.Z., Parmar, R.M., Blake, A.D. and Schaeffer, J.M. (2000) Somatostatin inhibits insulin and glucagon secretion via two different receptor subtypes-an in vitro study of islets from somatostatin receptor two knockout mice. Endocrinology 141:111-117.

Ye, Z., Gao, Y., Bakshi, R.K., Chen, M.H., Rohrer, S.P., Feighner, S.D., Pong, S.S., Howard, A.D., Blake, A., Birzin, E.T., Loco, L., Parmar, R.M., Chan, W.W., Schaeffer, J.M., Smith, R.G., Patchett, A.A. and Nargund, R.P. (2000) Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues. Bioorganic and Medicinal Chemistry Letters 10:5-8.

DiSalvo, J., Koch, G., Johnson, K.E., Blake, A.D., Daughtery, B.L., DeMartino, J.A., Sirotina-Meisher, A., Liu, J., Springer, M.S., Cascieri, M.A. and Sullivan, K.A. (2000) The CXCR4 ligand SDF-1 maintains high-affinity for receptors in both Gi-coupled and uncoupled states.
European Journal of Pharmacology 409:143-154.

Blake, A.D. (2001) Somatostatin receptor subtype 1 (sst₁) regulates forskolin and corticotropin-releasing hormone stimulated 3',5' cyclic adenosine monophosphate in embryonic cortical neurons. Neuropharmacology 40:590-596.

Strowski, M.Z., Dashkevicz, M.P., Parmar, R. M., Wilkinson, H., Kohler, M., Schaeffer, J.M. and Blake, A.D. (2002) Somatostatin receptor subtypes sst₂ and sst₅ regulate corticotropin-relasing hormone stimulated adrenocorticotropin secretion from AtT-20 cells. Neuroendocrinology 75:339-346.

Strowski, M.Z., Chen, H.Y., Trumbauer, M.E., Parmar, R.M., Kohler, M., Schaeffer, J.M., Blake, A.D., Wilkinson, H.A. and Zheng, B. (2002) Somatostatin receptor subtype 5 (sst₅) regulates insulin secretion-an in vitro study on islets isolated from sst5 knock out mice. Molecular Endocrinology, in press.

Blake, A.D. (2002) Dipyridamole protects embryonic cultures of rat cortical neurons from neurotoxic insult. (Submitted to Neuroscience Letters).



Resume & Research - Publications

Axen, K.V., Schubart, U.K., Blake, A.D. and Fleischer, N. (1983) Role of Ca2+ in secretagogue-stimulated breakdown of phosphatidylinositol in rat pancreatic islets. Journal of Clinical Investigation 72:13-21. Blake, A.D. and Strader, C.D. (1986) Potentiation of specific association of insulin with HepG2 cells by phorbol esters. Biochemical Journal 236:227-234. Dixon, R.A.F., Sigal, I.S., Rands, E., Register, R.B., Candelore, M.R., Blake, A.D. and Strader, C.D. (1987) Ligand binding to the b-adrenergic receptor involves its rhodopsin-like core. Nature 326:73-77. Strader, C.D., Sigal, I.S., Blake, A.D., Cheung, A.H., Register, R.B., Rands, E., Zemcik, B.A., Candelore, M.R. and Dixon, R.A.F. (1987) The carboxy terminus of the hamster beta-adrenergic receptor expressed in L cells is not required for receptor sequestration. Cell 49:855-863. Blake, A.D., Hayes, N.S., Slater, E.E. and Strader, C.D. (1987) Insulin receptor desensitization correlates with attenuation of tyrosine kinase activity but not of receptor endocytosis. Biochemical Journal 245:357-364. Blake, A.D., Mumford, R.A., Strout, H.V., Slater, E.E. and Strader, C.D. (1987) Synthetic segments of the b-adrenergic receptor are preferentially recognized by cAMP-dependent protein kinase or protein kinase C. Biochemical and Biophysical Research Communications 147:166-173. Strader, C.D., Dixon, R.A.F., Cheung, A.H., Candelore, M.R., Blake, A.D. and Sigal, I.S. (1987) Mutations that uncouple the b-adrenergic receptor from Gs and increase agonist affinity. Journal of Biological Chemistry 262:16439-16443. Blake, A.D. and Smith, R.G. (1991) Desensitization studies using perifused rat pituitary cells show that growth hormone-releasing hormone and His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 stimulate growth hormone release through distinct receptor sites. Journal of Endocrinology 129:11-19. Blake, A.D., Anthony, N.M., Chen, H.H., Harrison, J.B., Nathanson, N.M. and Sattelle, D.B. (1993) A Drosophila nervous system muscarinic acetylcholine receptor: transient functional expression and localization by immunocytochemistry. Molecular Pharmacology 44:716-724. Blake, A.D. (1994) Functional characterization of a cloned Drosophila muscarinic acetylcholine receptor. Doctoral Dissertation, University of Cambridge, UK. Harrison, J.B., Chen, H.H., Blake, A.D., Huskisson, N.S., Barker, P. and Sattelle, D.B. (1995) Localization in the nervous system of Drosophila melanogaster of a C-terminus anti-peptide antibody to a cloned Drosophila muscarinic acetylcholine receptor. Journal of Neuroendocrinology 7:347-352. Reisine, T., Law, S.F., Blake, A.D. and Tallent, M. (1996) Molecular mechanisms of opiate receptor coupling to G proteins and effector systems. Annals of the New York Academy of Sciences 780:168-175. Tallent, M., Blake, A.D. and Reisine, T. (1996) Molecular Biology of Opiate Receptors. In: Recombinant cell surface receptors: Focal point for therapeutic intervention. pp 35-55, Ed. M.J. Browne, R.G. Landes, UK. Blake, A.D., Bot, G. and Reisine, T. (1996) Structure-function analysis of the cloned opiate receptors: Peptide and small molecule interactions. Chemistry and Biology 3:967-972. Blake, A.D., Bot, G., Freeman, J.C. and Reisine, T. (1997) Differential opioid agonist regulation of the mouse m opioid receptor. Journal of Biological Chemistry 272:782-790. Blake, A.D., Bot, G., Li, S., Freeman, J. C. and Reisine, T. (1997) Differential agonist regulation of the human k opioid receptor. Journal of Neurochemistry 68:1846-1852. Bot, G., Blake, A.D., Li, S. and Reisine, T. (1997) Opioid regulation of the mouse d opioid receptor expressed in HEK 293 cells. Molecular Pharmacology 52:272-281. Blake A.D., Bot, G. and Reisine, T. (1997) Molecular pharmacology of the opioid receptors. In: Molecular neurobiology of pain. Progress in Pain Research and Management, volume 9, pp 259-273, Ed. D. Borsook, International Association for the Study of Pain Press, USA. Blake, A.D., Bot, G., Tallent, M., Law, S.F., Li, S., Freeman, J.C. and Reisine, T. (1997) Molecular regulation of the opioid receptors. Receptors and Channels 5:231-235. Bot, G., Blake, A.D., Li, S. and Reisine, T. (1998) Mutagenesis of a single amino acid in the rat m opioid receptor discriminates ligand binding. Journal of Neurochemistry 70:358-365. Bot, G., Blake, A.D., Li, S. and Reisine, T. (1998) Mutagenesis of the mouse d opioid receptor converts (-)buprenorphine from an agonist to an antagonist. Journal of Pharmacology and Experimental Therapeutics 284:283-290. Bot, G., Blake, A.D., Li, S. and Reisine, T. (1998) Fentanyl and its analogs desensitize the cloned m-opioid receptor. Journal of Pharmacology and Experimental Therapeutics 284:1207-1218. Bot, G., Blake, A.D. and Reisine, T. (1998) Stimulation of peptidergic receptors by peptide hormones and neurotransmitters: Studies of opioid receptors. In: Proteolytic and cellular mechanisms in prohormone and neuropeptide precursor processing, pp 191-211. Ed. V.Y.H. Hook, R.G. Landes Bioscience Publishers, Springer-Verlag, Heidelberg. Rohrer, S.P., Birzin, E.T., Mosley, R., Berk, S., Hutchins, S., Shen, D.-M., Xiong, Y., Hayes, E.C., Parmar, R.M., Foor, F., Mitra, S., Degrado, S., Shu, M., Klopp, J., Cai, S.-J., Blake, A., Chan, W.W.-S., Pasternak, A., Patchett, A.A., Smith, R.G., Chapman, K. and Schaeffer, J.M. (1998) Integration of high throughput screening and combinatorial chemistry for rapid identification of somatostatin receptor subtype selective analogs. Science 282: 737-740. Parmar, R.M., Chan, W.W.-S., Dashkevicz, M., Hayes, E.C., Rohrer, S.P., Smith, R.G., Schaeffer, J.M. and Blake, A.D. (1999) Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from anterior pituitary cells. Biochemical and Biophysical Research Communications 263:276-280. Strowski, M.Z., Parmar, R.M., Blake, A.D. and Schaeffer, J.M. (2000) Somatostatin inhibits insulin and glucagon secretion via two different receptor subtypes-an in vitro study of islets from somatostatin receptor two knockout mice. Endocrinology 141:111-117. Ye, Z., Gao, Y., Bakshi, R.K., Chen, M.H., Rohrer, S.P., Feighner, S.D., Pong, S.S., Howard, A.D., Blake, A., Birzin, E.T., Loco, L., Parmar, R.M., Chan, W.W., Schaeffer, J.M., Smith, R.G., Patchett, A.A. and Nargund, R.P. (2000) Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues. Bioorganic and Medicinal Chemistry Letters 10:5-8. DiSalvo, J., Koch, G., Johnson, K.E., Blake, A.D., Daughtery, B.L., DeMartino, J.A., Sirotina-Meisher, A., Liu, J., Springer, M.S., Cascieri, M.A. and Sullivan, K.A. (2000) The CXCR4 ligand SDF-1 maintains high-affinity for receptors in both Gi-coupled and uncoupled states. European Journal of Pharmacology 409:143-154. Blake, A.D. (2001) Somatostatin receptor subtype 1 (sst₁) regulates forskolin and corticotropin-releasing hormone stimulated 3',5' cyclic adenosine monophosphate in embryonic cortical neurons. Neuropharmacology 40:590-596. Strowski, M.Z., Dashkevicz, M.P., Parmar, R. M., Wilkinson, H., Kohler, M., Schaeffer, J.M. and Blake, A.D. (2002) Somatostatin receptor subtypes sst₂ and sst₅ regulate corticotropin-relasing hormone stimulated adrenocorticotropin secretion from AtT-20 cells. Neuroendocrinology 75:339-346. Strowski, M.Z., Chen, H.Y., Trumbauer, M.E., Parmar, R.M., Kohler, M., Schaeffer, J.M., Blake, A.D., Wilkinson, H.A. and Zheng, B. (2002) Somatostatin receptor subtype 5 (sst₅) regulates insulin secretion-an in vitro study on islets isolated from sst5 knock out mice. Molecular Endocrinology, in press. Blake, A.D. (2002) Dipyridamole protects embryonic cultures of rat cortical neurons from neurotoxic insult. (Submitted to Neuroscience Letters).
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